王宏伟

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王宏伟

 教授

                 

 
 
 
 
研究方向
                     

疾病分析与疾病分子标志物的甄定。

             

个人简历
                     

2016-01至今南京大学医学院 教授;

2009-09至2015-12南京大学医学院 副教授;

2007-08至2009-08 英国 爱丁堡大学医学院,博士后(Senior Research Associate); 

2004-06至2007-07 英国 帝国理工大学医学院 博士后(Research Associate);

2003-09至2004-05 英国 牛津大学医学院 访问学者(英国政府志奋领奖学金资助);

2001-07至2003-08 南方医科大学(原第一军医大学)免疫学教研室,讲师;

1995-09至2001-0吉林大学(原解放军军需大学),病原生物学,硕士/博士;

1990-09至1995-06吉林大学(原解放军军需大学),动物医学,本科/学士;

 

             

科研
                     

主要从事疾病的分子标记物筛查与鉴定,科研方向为炎症与代谢的相互作用,关注的疾病主要包括肿瘤恶病质及粘膜炎症等。先后主持国家自然科学基金三项、主持省部级基金课题五项,作为科研骨干参与国家863课题,973课题及国家公益性行业专项课题各一项。发表科研论文70余篇,申请并获得国家发明专利授权两项,获得省部级科研奖励三项,参编英文论著一部。目前为中国中药协会常任委员,江苏省免疫学会理事。

                         
主要论著
                     

1.Zhao C, Niu M, Song S, Li J, Su Z, Wang Y, Gao Q, Wang H*. Serum metabolomics analysis of mice that received repeated airway exposure to a water-soluble PM2.5 extract. Ecotoxicol Environ Saf. 2019 Jan 30;168:102-109. 

2.Chen G, Shen H, Zang L, Su Z, Huang J, Sun Y, Wang H*. Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism.  Int J Mol Med. 2018 Dec;42(6):3073-3082. 

3.Song S, Min H, Niu M, Wang L, Wu Y, Zhang B, Chen X, Liang Q, Wen Y, Wang Y, Yi L, Wang H*, Gao Q. S1PR1 predicts patient survival and promotes chemotherapy drug resistance in gastric cancer cells through STAT3 constitutive activation. EBioMedicine. 2018 Nov;37:168-176. 

4.Song S, Su Z, Xu H, Niu M, Chen X, Min H, Zhang B, Sun G, Xie S, Wang H*, Gao Q. Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1. Cell Death Dis. 2017 Feb 9;8(2):e2612. 

5.Xia N, Ye X, Hu X, Song S, Xu H, Niu M, Wang H*, Wang J. Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice. PLoS One. 2017 Mar 20;12(3):e0174260. 

6.Zhang B, Xie S, Su Z, Song S, Xu H, Chen G, Cao W, Yin S, Gao Q, Wang H*. Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling. Sci Rep. 2016 Feb 19;6:21132. 

7.Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H*, Chen H. Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney. Sci Rep. 2016 Dec 19;6:39470. 

8.Xie S, Su Z, Zhang B, Ge J, Song S, Sun G, Sun X, Yi L, Wang Y, Sun W, Wang H*, Gao Q*.SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice. J Invest Dermatol. 2015 135(7):1915-8 

9.Huo D, Ding J, Cui YX, Xia LY,  Li H, He J, Zhou ZY, Wang HW*, Hu Y*. X-ray CT and pneumonia inhibition properties of gold-silver nanoparticles for targeting MRSA induced pneumonia. Biomaterials. 2014 Aug;35(25):7032-41. Biomaterials.2014.04.092. 

10.Sun GB, Sun X, Wang M, Ye JX, Si JY, Xu HB, Meng XB, Qin M, Sun J, Wang HW*, Sun XB*. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression. Toxicol Appl Pharmacol. 2012 1;265(2):229-40. 

11.Sun GB, Qin M, Ye JX, Pan RL, Meng XB, Wang M, Luo Y, Li ZY, Wang HW*, Sun XB*. Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice. Toxicol Appl Pharmacol. 2013.29. 

12.Zhu L, Zhu Q, Zhang X, Wang H*. The correlation analysis of two common polymorphisms in STAT6 gene and the risk of asthma: a meta-analysis. PLoS One. 2013.4;8(7):e67657. 

13.Cui W, Chen L, Huang T, Gao Q, Jiang M, Zhang N, Zheng L, Feng K, Cai Y, Wang H*. Computationally identifying virulence factors based on KEGG pathways. Mol Biosyst. 7;9(6):1447-52. (2013) 

14.Su Z, Lu Y, Ge Y, Jiang J, Jia Z, Zhu F, Zhang M, Ji C, Tang Y, Wei J, Gao Q*, Wang H* Central nervous system involvement in systemic malignant atrophic papulosis (Degos disease): a case report. Int J Dermatol.  20.( 2013 ) 

15.Zhang X, Su Z, Zhang X, Hu C, Yu J, Gao Q*, Wang H*. Generation of Mycobacterium tuberculosis-specific recombinant antigens and evaluation of the clinical value of antibody detection for serological diagnosis of pulmonary tuberculosis. Int J Mol Med. 2013. 31(3):751-7. 

16.Wang H, Su Z, Schwarze J. Healthy, but not RSV-infected, lung epithelial cells profoundly inhibit T-cell activation. Thorax. 2009. 64(4): 283–290.

17. Wang H, Peters N, Schwarze J. Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection. J Immunol. 2006.177(9):6263-70.

18. Wang H, Peters N, Laza-Stanca V, Nawroly N, Johnston SL, Schwarze J.Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process. J Immunol. 2006.15;177(4):2536-42.

19.Wang HW, Cole D, Jiang WZ, Jin HT, Fu N, Chen ZL, Jin NY. Engineering and functional evaluation of a single-chain antibody against HIV-1 external glycoprotein gp120. Clin Exp Immunol. 2005 Jul;141(1):72-80. 

20.Wang H. Stem Cells in Toxicology and Medicine, Print ISBN: 9781119135418. 2016. Published by Wiley Online Library ,

                 

联系方式
                     

Email: hwang@nju.edu.cn

电话:83594755