刘   颖

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刘颖

(教授) 

 
 
 
 
研究方向
 
1) 基于智能响应材料的体内成像与精准治疗
2) 生物功能化表界面与即时现场分子诊断器件
3) 蛋白质超高灵敏分析测定新方法

 

个人简历
 
2000-2004 南京大学化学化工学院 学士
2004-2007 南京大学化学化工学院 分析化学 硕士
2007-2012 加州大学河滨分校 分析化学 博士
2012-2013 博世集团北美研发中心 助理研究员
2013-2015 加州大学戴维斯分校生物医学工程系 博士后

 

科研
 

主要研究方向集中于智能响应型纳米材料与功能化表界面设计、制备及其在体内成像与精准治疗、高灵敏生物分析与即时现场检测中的应用。针对常用体内成像与精准治疗方法中灵敏度欠缺、信号放大所需时间较长、特异性缺乏的一系列问题,在细胞内构建具有微纳结构的纳米反应器加速信号放大反应,实现活细胞内高效灵敏信号放大;并进一步利用外界刺激与细胞内微环境为响应开关,实现精准可控的药物递运与治疗。

 

主要论著
 
1)Kewei Ren,# Ying Liu,# Jie Wu, Yue Zhang, Jing Zhu, Min Yang, Huangxian Ju* A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery Nat. Commun. 2016, 7, 13580. 
2) Kewei Ren, Yifan Xu, Ying Liu*, Min Yang, Huangxian Ju* A responsive “Nano string light” for highly efficient mRNA imaging in living cells via accelerated DNA cascade reaction ACS Nano 2018, 12, 263.
3)Kewei Ren, Yue Zhang, Xiaobo Zhang, Ying Liu*, Min Yang, Huangxian Ju* In situ siRNA assembly in living cells for gene therapy with microRNA triggered cascade reactions templated by nucleic acids ACS Nano 2018, 12, 10797.
4)Jingxing Guo,# Ying Liu,# Yunlong Cheng, Jianqi Li, Huangxian Ju* A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms Chem. Sci. 2018, 9, 5906.
5)Yue Zhang, Kewei Ren, Xiaobo Zhang, Zhicong Chao, Yuqin Yang, Deju Ye, Zhihui Dai, Ying Liu*, Huangxian Ju* Photo-tearable tape close-wrapped upconversion nanocapsules for near-infrared modulated efficient siRNA delivery and therapy Biomaterials 2018, 163, 55.
6)Xiao Meng, Junjie Hu, Zhicong Chao, Ying Liu*, Huangxian Ju, Quan Cheng* Thermoresponsive arrays patterned via photoclick chemistry: smart MALDI plate for protein digest enrichment, desalting, and direct MS analysis ACS Appl. Mater. Interfaces 2018, 10, 1324.
7)Ying Liu, Michael C. Young, Orly Moshe, Quan Cheng*, Richard J Hooley* A membrane-bound synthetic receptor that promotes growth of a polymeric coating at the bilayer-water interface Angew. Chem. Int. Ed. 2012, 51, 7748.
8)Chuanbo Gao,# Zhenda Lu,# Ying Liu,# Qiao Zhang, Miaofang Chi, Quan Cheng, Yadong Yin* Highly stable silver nanoplates for surface plasmon resonance biosensing Angew. Chem. Int. Ed. 2012, 51, 5629. (#共同一作)
9)Ying Liu, Puhong Liao, Quan Cheng* Richard J Hooley* Protein and small molecule recognition properties of deep cavitands in a supported lipid membrane determined by calcination-enhanced SPR spectroscopy J. Am. Chem. Soc. 2010, 132, 10383.
10)Ying Liu, Ying Liu, Zimple Matharu, Ali Rahimian, Alexander Revzin* Detecting multiple cell-secreted cytokines from the same aptamer functionalized electrode Biosens. Bioelectron. 2015, 64, 43.
11)Ying Liu, Quan Cheng* Detection of membrane binding proteins by surface plasmon resonance with an all-aqueous amplification scheme Anal. Chem. 2012, 84, 3179.
12)Ying Liu, Yi Dong, Jessica Jauw, Matthew J Linman, Quan Cheng* Highly sensitive detection of protein toxins by surface plasmon resonance with biotinylation based inline atom transfer radical polymerization amplification Anal. Chem. 2010, 82, 3679.

 

联系方式
 

025-89681918
办公室:E301; 实验室:A214,215