周国华

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周国华

(主任药师、教授) 

 
 
 
 
研究方向
 
研究方向为分子诊断新方法,主要研究领域为药物基因组学、单细胞分析、个体化给药等

 

个人简历
 

周国华,1964年12月3日生。1998年获清华大学理学博士学位,1999年5月以高级访问研究员身份,在日本先后留学5年。2001年被聘为研究员,2012年改聘为主任药师。自2012年2月至今,任南京大学医学院附属金陵医院药理科主任,南京大学医学院教授、博士生导师,南京大学生命分析化学国家重点实验室固定成员。享受政府特殊津贴,为江苏省青年科技奖获得者、江苏省有突出贡献中青年专家。2016年获江苏省科教兴卫工程优秀领军人才与医学创新团队奖;2017年获江苏省创新争先奖章。现任中国药理学会分析药理专业委员会副主任委员、江苏省药学会药物基因组专业委员会主任委员。兼任《医学研究生学报》、《东南国防医药》杂志副主编,《药物分析杂志》编委。

 

科研
 

先后主持国家级科研课题(含子课题)12项,包括国家科技重大专项4项、国家863子课题1项、国家973子课题2项、国家自然科学基金课题5项。获教育部科技进步一等奖1项、省部级科技进步二等奖5项、华夏医学科技一等奖1项;获授权国家发明专利17项;获国家新药证书4项。在Nucleic Acids Res, Genome Biol, Angew Chem Int Ed, Chem Sci, Anal Chem发表SCI论文近百篇,主编专著4部,包括由Springer出版的英文专著《Advances and Clinical Practice of Pyrosequencing》、苏州大学出版社出版的《SNP检测技术与个体化药物治疗》、, 江苏凤凰科学技术出版社出版的《基因突变检测技术与精准给药》等。

 

主要论著
 
主要研究论文:
1.Xu S., Cao S., Zou B., Yue Y., Gu C., Chen X., Wang P., Dong X., Xiang Z., Li K., Zhu M., Zhao Q., and Zhou G.*, An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease. Genome Biol, 2016, 17(1): 186.  IF=13.214
2.Liu Y. L., Wu H. P., Zhou Q., Song Q. X., Rui J. Z., Guan X. X., Zhou G. H., and Zou B.   invasive reaction for a sensitive DNA logic sensor for mutation detection. Chem Sci, 2018, 9(6): 1666-1673.  IF=9.063
3.Wang J., Zou B., Ma Y., Ma X., Sheng N., Rui J., Shao Y., and Zhou G., Closed-Tube PCR with Nested Serial Invasion Probe Visualization Using Gold Nanoparticles. Clin Chem, 2017, 63(4): 852-860.  IF=8.636
4.Lu Y., Ma X., Wang J., Sheng N., Dong T., Song Q., Rui J., Zou B., and Zhou G., Visualized detection of single-base difference in multiplexed loop-mediated isothermal amplification amplicons by invasive reaction coupled with oligonucleotide probe-modified gold nanoparticles. Biosens Bioelectron, 2017, 90: 388-393.  IF=8.173
5.Liu Y., Wu H., Zhou Q., Song Q., Rui J., Zou B., and Zhou G., Digital quantification of gene methylation in stool DNA by emulsion-PCR coupled with hydrogel immobilized bead-array. Biosens Bioelectron, 2017, 92: 596-601.  IF=8.173
6.Zou B., Cao X., Wu H., Song Q., Wang J., Kajiyama T., Kambara H., and Zhou G., Sensitive and specific colorimetric DNA detection by invasive reaction coupled with nicking endonuclease-assisted nanoparticles amplification. Biosens Bioelectron, 2015, 66: 50-54.  IF=8.173
7.Huang H., Jin L., Yang X., Song Q., Zou B., Jiang S., Sun L., and Zhou G., An internal amplification control for quantitative nucleic acid analysis using nanoparticle-based dipstick biosensors. Biosens Bioelectron, 2013, 42: 261-266.  IF=8.173
8.Chen Z., Miao L., Liu Y., Dong T., Ma X., Guan X., Zhou G., and Zou B., A universal genotyping-microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions. Chem Commun (Camb), 2017, 53(96): 12922-12925.  IF=6.29
9.Zou B., Song Q., Wang J., Liu Y., and Zhou G., Invasive reaction assisted strand-displacement signal amplification for sensitive DNA detection. Chem Commun (Camb), 2014, 50(89): 13722-13724.  IF=6.29
10.Chen Z., Fu X., Zhang X., Liu X., Zou B., Wu H., Song Q., Li J., Kajiyama T., Kambara H., and Zhou G., Pyrosequencing-based barcodes for a dye-free multiplex bioassay. Chem Commun (Camb), 2012, 48(18): 2445-2447.  IF=6.29
11.Liang C., Chu Y., Cheng S., Wu H., Kajiyama T., Kambara H., and Zhou G., Multiplex LAMP detection by sequence-based barcodes coupled with NEase-mediated Pyrosequencing. Anal Chem, 2012, 84(8): 3758-3763.  IF=6.042
12.Deng L., Qi Z., Zou B., Wu H., Huang H., Kajiyama T., Kambara H., and Zhou G., Digital detection of multiple minority mutants in stool DNA for noninvasive colorectal cancer diagnosis. Anal Chem, 2012, 84(13): 5645-5652.  IF=6.042
13.Wang J., Zou B., Rui J., Song Q., Kajiyama T., Kambara H., and Zhou G., Exponential amplification of DNA with very low background using graphene oxide and single-stranded binding protein to suppress non-specific amplification. Microchimica Acta, 2014, 182(5-6): 1095-1101.  IF=5.705
14.Song Q., Qi X., Jia H., He L., Kumar S., Pitman J. L., Zou B., and Zhou G., Invader Assisted Enzyme-Linked Immunosorbent Assay for Colorimetric Detection of Disease Biomarkers Using Oligonucleotide Probe-Modified Gold Nanoparticles. J Biomed Nanotechnol, 2016, 12(4): 831-839.  IF=5.068
专著、专章:
1.Zhou Guohua, Song Qinxin. Advances and Clinical Practice of Pyrosequencing, ISBN 978-1-4939-3308-2, 2016. 
2.周国华, 宋沁馨. 基因突变检测技术与精准给药, 江苏凤凰科学技术出版社, ISBN 978-7-5537-8032-0, 2018. 
3.周国华. SNP检测技术与个体化药物治疗,苏州大学出版社,ISBN 978-7-5672-1212-1, 2015.
4.Zhou Guohua, Prenatal Diagnosis of Chromosomal Aneuploidies by Quantitative Pyrosequencing, ISBN 978-1-4939-2715-9, 2015, p123-132. 

 

联系方式
 

ghzhou@nju.edu.cn