韩晓冬

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韩晓冬

(教授) 

 
 
 
 
研究方向
 

生殖生物学、干细胞生物学

 

个人简历
 

1961年生。1984年毕业于南京大学生物系,获学士学位;1987年于南京大学生物系获硕士学位;2004年于南京大学生命科学院获博士学位。1987年起在南京大学医学院任教,2001年作为高级访问学者赴美国哈佛大学医学院Beth Israel Deaconess Medical Center开展合作研究,2004年被聘为教授,2006年被聘为博士生导师,2010年获南京大学“我最喜爱的教师” 称号,2017年获宝钢教育基金会优秀教师奖。长期从事生殖生物学、干细胞生物学研究,主持并参与国家自然科学基金、国家“973计划”、教育部骨干教师基金、江苏省自然科学基金等研究项目,在国内外学术刊物共发表论文170余篇。兼任教育部高等学校基础医学类专业教学指导委员会委员,江苏省高等学校医药教育研究会副理事长,江苏省解剖学会理事长。

 

科研
 

1)研究重要环境污染物对生殖系统影响的机制,寻找可作为环境风险评估的关键分子标志物;
2)研究干细胞的体外诱导分化及体内条件下干细胞定向分化的调控机制,特别专注肺间质干细胞在特发性肺纤维化发病过程中的作用机制研究,筛选可用于其诊断、预后判断及病情监控的关键生物分子,并开展疾病干预的基础研究。

 

主要论著
 
(近三年):
1.Xiannan Meng, Haoran Peng, Yuanzhen Ding, Ling Zhang, Jingping Yang*, Xiaodong Han*. A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity. Science of the Total Environment. 2019, 667: 563–577.
2.Jing Wang, Yabing Chen, Changliang Zhang, Zou Xiang, Jie Ding*, Xiaodong Han*. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials. 2019, 373: 504–518.
3.Xiaoqin Yin, Bo Wang, Weidong Gan, Wenyuan Zhuang, Zou Xiang, Xiaodong Han* and Dongmei Li*. TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. Journal of Experimental & Clinical Cancer Research. 2019, 38:119
4.Zhenzhen Zhang, Luxuan Suo, Yabing Chen, Li Zhu, Guiping Wan*, and Xiaodong Han*. Endometriotic Peritoneal Fluid Promotes Myofibroblast Differentiation of Endometrial Mesenchymal Stem Cells. Stem Cells International. Volume 2019, Article ID 6183796.
5.Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan* and Xiaodong Han*. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway. Cell Communication and Signaling. 2019, 17:45.
6.Hou Jiwei, Shi Jingyan, Chen Ling, Lv Zhongyang, Chen Xiang, Cao Honghui, Xiang Zou, and Han Xiaodong*. M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Communication and Signaling. 2018 ,16:89,
7.Pan Chun, Chen Yabing, Xu Tianchi, Wang Jing, Li Dongmei*, and Han Xiaodong*. Chronic exposure to microcystin-leucine-arginine promoted proliferation of prostate epithelial cells resulting in benign prostatic hyperplasia. Environmental Pollution. 2018, 242: 1535-1545.
8.Wang Jing, Chen Yabing, Chen Zhangpeng, Xiang Zou, Ding Jie*, and Han Xiaodong*. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicology and Environmental Safety. 2018, 163:391–399.
9.Ding Jie, Wang Jing, Jin Haibo, Xia Tianjiao, Chen Yi, Wu Jiang, and Han Xiaodong*. Microcystin-LR reduces the synthesis of gonadotropin-releasing hormone by activating multiple signaling pathways resulting in decrease of testosterone in mice. Science of the Total Environment. 2018, 643:496–506.
10.Chen Xiang, Shi Chaowen, Co Honghui, Chen Ling, Hou Jiwei, Xiang Zou, Hu Kebin, and Han Xiaodong*. The hedgehog and Wnt/β-catenin system machinery mediate myofibroblast differentiation of LR-MSCs in pulmonary fibrogenesis. Cell Death Disease. 2018, 9:639.
11.Chen Yabing, Wang Jing, Chen Xiang, Li Dongmei, Han Xiaodong*. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels. Aquatic Toxicology. 2018, 199:116-126.
12.Yin Xiaoqin, Ma Tan, Han Ruitong, Ding Jie, Zhuang Huan, Han Xiaodong*, and Li Dongmei*. MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)–induced proliferation by targeting Rasd1 in Sertoli cells. Toxicology in Vitro. 2018, 47:79-88
13.Zhang Ling, Meng Xiannan, Xiang Zou, Li Dongmei*, and Han Xiaodong. Roles of mmu_piR_003399 in Microcystin-Leucine Arginine-Induced Reproductive Toxicity in the Spermatogonial Cells and Testis. Toxicological sciences. 2018,161(1):159–170.
14.Hou Jiwei, Ma Tan, Cao Honghui, Chen Yabing, Wang Cong, Chen Xiang, Xiang Zou, and Han Xiaodong*. TNF-α-induced NF-κB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis. J Cell Physiol. 2018 ,233(3):2409-2419.
15.Chen Yabing, Wang Jing, Han Xiaodong*, et al. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences. 2018, 75(6):1117-1132.
16.Cao Honghui, Wang Cong, Chen Xiang, Hou Jiwei, Xiang Zou, Shen Yi, and Han Xiaodong*. Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis. Scientific Reports. 2018, 8:13644.
17.Ma Tan, Yin Xiaoqin, Ruitong Han, Ding Jie, Zhuang Huan, Han Xiaodong*, and Dongmei Li*. Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. Int J Environ Res Public Health. 2017,14(10): 1284.
18.Liangying Zhu, Xiao Fu,Xiang Chen, Xiaodong Han* and Ping Dong*.M2 macrophages induce EMT through the TGF-b/Smad2 signaling pathway. Cell Biology International. 2017,41(9):960-968.
19.Yabing Chen, Jing Wang, Qin Zhang, Zou Xiang, Dongmei Li, Xiaodong Han*.Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. Environmental Pollution. 2017,229:964-975.
20.Hui Zhang, Lihui Wang, Song Shen, Chenchen Wang, Zou Xiang, Xiaodong Han*, Dongmei Li*. Toxic effects of microcystin-LR on the development of prostate in mice. Toxicology. 2017, 380:50-61.
21.Ling Zhang, Hui Zhang, Huan Zhang, Mikael Benson, Xiaodong Han*, Dongmei Li*. Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food and Chemical Toxicology. 2017, 105:177-185.
22.Xiaoyan Li, Xin Zhuang, Tianchi Xu, Min Mao, Cong Wang, Yabing Chen, Xiaodong Han*, Jiang Wu* Expression analysis of microRNAs and mRNAs in ovarian granulosa cells after microcystin-LR exposure, Toxicon. 2017,129:11-19.
23.Xiang Chen,Chaowen Shi,Cong Wang,Weilin Liu,Yanhong Chu,Zou Xiang,Kebin Hu,Ping Dong and Xiaodong Han*.The role of miR-497-5p in myofibroblast differentiation of LR-MSCs and pulmonary fibrogenesis. Scientific Reports. 2017, 7:40958.
24.Ding J, Wang J, Xiang Z, Diao W, Su M, Shi W, Wan T, Han X*. The Organic anion transporting polypeptide 1a5 is a pivotal transporter forthe uptake of microcystin-LR bygonadotropin-releasing hormone neurons. Aquat Toxicol. 2017,182:1-10.

 

联系方式
 
Email: hanxd@nju.edu.cn   电话:83686497