吴稚伟

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吴稚伟

(教授)

 

 
 
 
 
研究方向
 

病毒感染,免疫,抗病毒机制,公共卫生

 

个人简历
 
2005-今:教授,博导,南京大学医学院,公共健康医学中心主任
2008-今:南京大学生命分析化学国家重点实验室,副主任
2008-今:Associate Member, 英国南汉普顿大学
2007-今:兼职副教授,纽约大学医学院
2000-06: 高级研究员,宾夕法尼亚大学Leon Levy研究中心
1997-2000: 助理教授,洛克菲勒大学,美国
1994-97: NIH Fellow, 纽约大学医学院微生物学系
1992-94: Aaron Diamond Fellow, 纽约大学公共卫生研究院
1990-1992:博士后,美国私立纽约大学公共卫生学院
1986-1990:英国爱丁堡大学,获博士学位
1978-1982:南京大学生物学系,获学士学位

 

科研
 

主要科研方向是病毒-宿主相互作用,抗病毒免疫,特别是抗体,B细胞免疫以及抗病毒机理。研究的病原主要有HIV, EV71, SFTSV, HSV以及高致病性病毒。课题组还建有完整的纳米单链抗体诱导,研制及抗体工程平台,研发诊断和治疗性抗体。主持国家科技重大专项四项,其中担任二项责任科学家,二项课题负责人;担任“973”重大基础研究项目课题负责人,一项基金委国际合作项目负责人以及二项基金委面上项目负责人。现担任美国MPTi指导委员会委员,世界卫生组织(WHO)SRHR指南制定小组成员,Frontiers in Immunology副主编。

 

主要论著
 
近5年代表性论著:
1.Siwei Song, Min Qiu, Ying Chu, Deyan Chen, Xiaohui Wang, Airong Su, Zhiwei Wu*. Downregulation of Cellular c-Jun N-Terminal Protein Kinase and NFk-B Activation by Berberine May Result in Inhibition of HerpesSimplex Virus Replication.Antimicrobial Agents and Chemotherapy (2014), 58(9):5068-5078. 
2.Yuxuan Fu, Wentao Xu, Deyan Chen, Chunhong Feng, Li Zhang, Xiaohui Wang, Xiaowen Lv, Nan Zheng, Yu Jin, Zhiwei Wu*. Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication. Antiviral Research (2015) 124:43-53. Selected as Highlighted Article by AVR for Jan. 2016. 
3.Deyan Chen, Airong Su, Yuxuan Fu, Xiaohui Wang, XiaowenLv, Wentao Xu, Shijie Xu,Huanru Wang, Zhiwei Wu. Harmine blocks herpes simplex virus infection through downregulating cellular NF-kB and MAPK pathways induced by oxidative stress.Antiviral Research (2015) 123:27-38.
4.Lin Cheng, Xian Tang, Li Liu, Jie Peng, Kenji Nishiura, Allen Ka Loon Cheung, JiaGuo, Xilin Wu, Hang Ying Tang, Minghui An, Jingying Zhou, KaWai Cheung, Hui Wang, Xinyuan Guan, Zhiwei Wu*,Zhiwei Chen*. Monoclonal antibodies specifical against human Δ42PD1: a novelimmunoregulator potentially involved in HIV-1 and tumor pathogenesis.MAbs. 2015 May;7(3):620-9.
5.Yuxuan Fu, Li Zhang, Fang Zhang, Ting Tang, Chunhong Feng, Yu Jin, Zhiwei Wu*.Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. PloS Pathogen(2017). 13(9):e1006611. https://doi.org/10.1371/journal. ppat. 1006611. 
6.Deyan Chen, Chunhong Feng, Xiaoyan Tian,Nan Zheng, Zhiwei Wu*. Promyelocytic Leukemia restricts enterovirus 71 replication by inhibiting autophagy. Front. Immunol.(2018)9.1268. doi: 10.3389/fimmu.2018.01268. 
7.Peixin Song, Nan Zheng, Yong Liu, Chen Tian, Xilin Wu, Xiaohua Ma, Deyan Chen, Xue Zou, Guiyang Wang, Huanru Wang, Yongyang Zhang, Sufang Lu, Chao Wu, Zhiwei Wu*. Deficient humoral response and disrupted B cell immunity are associated with fatal SFTSV infection. Nature Communications(2018) 9:3328/DOI: 10.1038/s41467-018-05746-9. 
8.Li Zhang, Yuxuan Fu, Huanru Wang, Yajie Guan, Weiwen Zhu, MengdiGuo, Nan Zheng, Zhiwei Wu*. Severe Fever with Thrombocytopenia Syndrome Virus-induced macrophage differentiation is regulated by miR-146. Front. Immunol. (2019) 10:1095. doi: 10.3389/fimmu.2019.01095. 
9.Yuxuan Fu, Li Zhang, Rui Zhang, Shijie Xu, Huanru Wang, Yu Jin, Zhiwei Wu*. Enterovirus 71 suppresses miR-17-92 cluster through up-regulating methylation of the miRNA promoter. Front. Microbiol.(2019)10:625.doi: 10.3389/fmicb.2019.00625.
10.Tian Zou and Zhiwei Wu*. Self-sampling for human papilloma virus can save lives in China. British Medical Journal (2019) 365 suppl. 2, 28 (Invited contribution).

 

联系方式
 

Email:wzhw@nju.edu.cn
电话:025-83686092