李冬梅

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李冬梅

(副教授博士生导师) 

 
 
 
 
研究方向
 

泌尿生殖系统疾病生物标志物筛选

 

个人简历
 

1997年南京医科大学获临床医学学士学位,2007年南京大学生命科学院获生理学博士学位。2007年起任南京大学医学院讲师、副教授。2011年成为江苏省第八批“六大人才高峰”高层次人才培养对象。2013年11月至2014年10月赴美国国立卫生院国家癌症研究所访学。发表SCI收录论文和国内核心期刊论文40余篇,合著编书4册/部。主持国家和省部级基金及横向课题多项。

 

科研
 

1)环境污染与男性生殖健康;2)泌尿生殖系肿瘤发生机制和干预研究。

 

主要论著
 

近五年:

1.Yin X, Wang B, Gan W*, Zhuang W, Xiang Z, Han X*, 李冬梅(通讯作者). TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas. J Exp Clin Canc Res, 2019, Mar 8, 38(1): 119. 
2.Ruitong Han, Ling Zhang, Weidong Gan*, Kai Fu, Ke Jiang, Jie Ding, Jiang Wu, Xiaodong Han*, 李冬梅(通讯作者)piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate. 2019 May;79(7):798-812. 
3.Ning Liu, Weidong Gan*, Feng Qu, Zhen Wang, Wenyuan Zhuang, SezimAgizamhan, Linfeng Xu, JuanjuanYin,Hongqian Guo, and 李冬梅(通讯作者). Does the Fuhrman or World Health Organization/International Society of Urological Pathology Grading System Apply to the Xp11.2 Translocation Renal Cell Carcinoma?A 10-Year Single-Center Study. Am J Pathol. 2018 Apr;188(4):929-936.
4.Ling Zhang, Xiannan Meng, Zou Xiang, 李冬梅(通讯作者), Xiaodong Han*. Roles of mmu_piR_003399 in microcystin-leucine arginine (MC-LR)-induced reproductive toxicity in the spermatogonial cells and testis. Toxicological Sciences, 2018 Jan 1;161(1), 2018, 159–170 
5.Xiaoqin Yin, Tan Ma, Ruitong Han, Jie Ding, Huan Zhang*, Han Xiaodong*, 李冬梅(通讯作者), MiR-301b-3p/3584-5p enhances low-dose mono-n-butyl phthalate (MBP)–induced proliferation by targeting Rasd1 in Sertoli cells. Toxicol In Vitro. 2018 Mar;47:79-88.
6.Chen Yabing, Wang Jing, Pan Chun, 李冬梅(通讯作者), Han Xiaodong. Microcystin-leucine arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and molecular life sciences, Cell. Mol. Life Sci. 2018 Mar; 75:1117–1132
7.Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han and 李冬梅(通讯作者). Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat. International Journal of Environmental Research and Public Health. 2017, Oct 24;14, 1284.
8.Lei Xiong, Xiancheng Chen, Ning Liu, Zhen Wang, Baolei Miao, Weidong Gan*, 李冬梅(通讯作者), Hongqian Guo. PRCC-TFE3 dual-fusion FISH assay: A new method for identifying PRCC-TFE3 renal cell carcinoma in paraffin-embedded tissue. PLoS ONE 2017 Sep 26; 12(9): e0185337.
9.Zhang Ling, Zhang Hui, Zhang Huan, Benson Mikael, Han Xiaodong, 李冬梅(通讯作者). Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring. Food Chem Toxicol. 2017 Apr 13;105:177-185.
10.Hui Zhang, Lihui Wang, Song Shen, Chenchen Wang, Zou Xiang, Xiaodong Han*, 李冬梅(通讯作者). Toxic effects of microcystin-LR on the development of prostate in mice. Toxicology. 2017 Apr 1;380:50-61. 
11.Zhen Wang, Ning Liu, Weidong Gan, Xiaogong Li, Gutian Zhang, 李冬梅(通讯作者)  and Hongqian Guo. Postoperative recurrence of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion. Journal of International Medical Research. 2017 Aug;45(4):1287-1296.
12.Yabing Chen, Yuan Zhou, Jing Wang, Lihui Wang, Xiang Zou, 李冬梅(通讯作者), and Xiaodong Han*. Microcystin-Leucine Arginine Causes Cytotoxic Effects in Sertoli Cells Resulting in Reproductive Dysfunction in Male Mice. Sci Rep. 2016 Dec 15; 6:39238.
13.Xiancheng Chen, Lei Xiong, Baolei Miao, Ning Liu, Zhen Wang, Weidong Gan*, 李冬梅(通讯作者), Hongqian Guo. The value of ASPL-TFE3 dual-color single-fusion FISH assay in diagnosing alveolar soft part sarcoma. Int J Clin Exp Pathol 2016;9(10):10581-10586
14.Ning Liu, Zhen Wang, Weidong Gan*, Lei Xiong, Baolei Miao, Xiancheng Chen, Hongqian Guo, 李冬梅(通讯作者). Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusions: Clinical Features, Treatments and Prognosis. PLoS One. 2016 Nov 28;11(11):e0166897.
15.Xiannan Meng , Ling Zhang, Xiang Chen, Zou Xiang, 李冬梅(通讯作者) and Xiaodong Han*. miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice. Toxins (Basel). 2016 Sep 6;8(9). pii: E260.
16.Lihui Wang , Pan Zhang , Xiannan Meng, Xiaoqian Lin, Ye Liu, Weidong Gan*, Xiaodong Han*, 李冬梅(通讯作者). Correlation between the germline methylation status in ERβ promoter and the risk in prostate cancer: a prospective study. Familial Cancer 2016 Apr;15(2):309-15. 
17.Ruoyu Wang, Xiaoqin Yin, Hui Zhang, JiweiWang, Lin Chen, Jingwen Chen, Xiaodong Han, Zou Xiang, and 李冬梅(通讯作者). Effects of a Moderately Lower Temperature on the Proliferation and Degranulation of Rat Mast Cells. J Immunol Res. 2016;2016: 8439594.
18.Yuan Zhou, Hui Wang, Cong Wang, XuefengQiu, Mikael Benson, Xiaoqin Yin, Zou Xiang, 李冬梅(通讯作者), Xiaodong Han*. Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity. Toxicology and Applied Pharmacology 2015 Aug 15;287(1):1-8.
19.Weidong Gan, Ming Zhou, Zou Xiang, Xiaodong Han and 李冬梅(通讯作者). Combined Effects of Nonylphenol and Bisphenol A on the Human Prostate Epithelial Cell Line RWPE-1. Int. J. Environ. Res. Public Health 2015 Apr 14;12(4):4141-55.
20.Yuan Zhou, Zou Xiang, 李冬梅(通讯作者), Xiaodong Han*. Regulation of Microcystin-LR-Induced Toxicity in Mouse Spermatogonia by miR-96. Environmental Science and Technology. 2014 Jun 3;48(11):6383-90.
21.Yang Hu, Ruoyu Wang, Zou Xiang, Weiping Qian, Xiaodong Han*, 李冬梅(通讯作者). Antagonistic Effects of a Mixture of Low-Dose Nonylphenol and Di-N-Butyl Phthalate (Monobutyl Phthalate) on the Sertoli Cells and Serum Reproductive Hormones in Prepubertal Male Rats In Vitro and In Vivo. Plos One. 2014 Mar 27;9(3):e93425.
22.Yang Hu, Ruoyu Wang, Zou Xiang, Weiping Qian, Xiaodong Han*, 李冬梅(通讯作者). Mixture effects of nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the tight junctions between Sertoli cells in male rats in vitro and in vivo. Exp ToxicolPathol. 2014 Dec;66(9-10):445-54.
1.英文专著:李冬梅 and Xiaodong Han. Methyl tert-butyl ether. Reproductive and Developmental Toxicology. Edited by Ramesh C. Gupta. Academic Press. ISBN: 978-0-12-382032-7. page: 617-621.
2.中国,发明专利,甘卫东,陈显成,叶庆,陈绍宇,郭宏骞,李冬梅,肾癌的荧光原位杂交多克隆分离探针及其试剂盒应用,授权,2016.06.08,201410216034.4
3.甘卫东,屈峰,徐林锋,李冬梅,李笑弓. Xp11.2 易位/TFE3 基因融合相关性肾癌诊断体系的构建及临床应用. 2018 年江苏省教育教学与研究成果奖(研究类),三等奖.

 

联系方式
 

http://med.nju.edu.cn/ad/4c/c10880a306508/page.htm