张春妮

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张春妮

(教授,博士生导师) 

 
 
 
 
研究方向
 

疾病分子标志物的基础与临床研究

 

个人简历
 
1963年生;
1984年南京大学生物系毕业,获学士学位;
1987年南京大学生化系获硕士学位;
2005年南京大学生命科学院获博士学位;
1987年至今在南京大学医学院附属金陵医院工作;
1997年至1998年作为笹川医学奖学金研究者在日本熊本大学医学院研修;
2008年为南京大学兼职教授;
2011年为南京大学博士生导师;
现任:南京大学医学院附属金陵医院检验科副主任,主任技师.

 

科研
 

主持国家自然科学基金4项,作为技术骨干参与国家“973计划”子项目1项。曾获国家教育部科学技术一等奖(第二完成人)、国家教育部技术发明一等奖(第四完成人)、中华医学会科技进步二等奖(第二完成人)、中国人民解放军医疗成果二等奖(第一完成人)等多项成果奖。以第一发明人获得授权的国家发明专利3项。在国内外发表论文150多篇,以第一或通讯作者在Clin Chem、Cancer Res等杂志上发表SCI论文48篇,其中5篇SCI论文曾入选临床医学领域十年来全球Top 1%“ESI”高被引论文.

 

主要论著
 
1.Chen Y, Wang C, Yu H, Ding M, Zhang C, Lu X, Zhang CY, Zhang C*. Increased urinary exosomal microRNAs in children with idiopathic nephrotic syndrome. EBiomedicine 2019,39,552-561
2.Ding M, Lu X, Wang C, Zhao Q, Ge J, Xia Q, Wang J, Zen K, Zhang CY, Zhang C*. The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma. Cancer Res 2018, 78, 6771-6784
3.Ding M, Wang C, Lu X, Zhang C, Zhou Z, Chen X, Zhang CY,  Zen K, Zhang C*.Comparison of four commercial exosome isolation kits for circulating exosomal microRNA profiling. Anal Bioanal Chem  2018,410,3805-3814
4.Zhang K , Chen J , Zhou H, Chen Y , Zhi Y , Zhang B , Chen L , Chu X , Wang R , Zhang C*. PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib. Cell Death Dis 2018, 9, 312 
5.Jia Y ,  Lu H, Wang C , Wang J , Zhang C , Wang F , Zhang C*. miR-25 is upregulated before the occurrence of esophageal squamous cell carcinoma. Am J Transl Res 2017,9,4458-4469 
6.Ding M, Wang X, Wang C, Liu X, Zen K, Wang W, Zhang CY, Zhang C*. Distinct expression profile of HCMV encoded miRNAs in plasma from oral lichen planus patients. J Transl Med 2017,15,1-12
7.Wang C, Wu C, Yang Q, Ding M , Zhong J, Zhang CY, Ge J, Wang J, Zhang C*. miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B. Oncotarget 2016,7,73888-73902
8.Yan Y, Wang C, Zhou W, Shi Y, Guo P, Liu Y, Wang J, Zhang CY, Zhang C*. Elevation of circulating miR-210-3p in high-altitude hypoxic environment. Front Physiol 2016,7, Article 84,1-9
9.Wang C, Hu J, Lu M, Gu H, Zhou X, Chen X, Zen K, Zhang CY, Zhang T, Ge J, Wang J, Zhang C*. A panel of five serum miRNAs as a potential diagnostic tool for early-stage renal cell carcinoma. Sci Rep 2015, 5, 7610
10.Wu C, Wang C, Guan X, Liu Y, Li D, Zhou X, Zhang Y, Chen X, Wang J, Zen K, Zhang CY, Zhang C*. Diagnostic and prognostic implications of a serum miRNA panel in oesophageal squamous cell carcinoma. PLoS One 2014, 9,e92292
11.Luo Y, Wang C, Chen X, Zhong T, Cai X, Chen S, Shi Y, Hu J, Guan X, Xia Z, Wang J, Zen K, CY, Zhang C*. Increased serum and urinary microRNAs in children with idiopathic nephrotic syndrome. Clin Chem 2013, 59,658–666 
12.Yang C, Wang C, Chen X, Chen S, Zhang Y, Zhi F, Wang J, Li L, Zhou X, Li N, Pan H, Zhang J, Zen K, Zhang CY, Zhang C*. Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas. Int J Cancer 2013,132, 116–127
13.Wang C, Yang C, Chen X, Yao B, Yang C, Zhu C, Li L, Wang J, Li X, Shao Y, Liu Y, Ji J, Zhang J, Zen K, Zhang CY, Zhang C*. Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility. Clin Chem 2011,57,1722–1731
14.Liu R, Zhang C (co-first author), Hu Z, Li G, Wang C, Yang C, Huang D, Chen X, Zhang H, Zhuang R, Deng T, Liu H, Yin J, Wang S, Zen K, Ba Y, Zhang CY. A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer 2011, 47,784–791
Zhang C*, Wang C, Chen X, Yang C, Li K, Wang J, Dai J, Hu Z, Zhou X, Chen L, Zhang Y, Li Y, Qiu H, Xing J, Liang Z, Ren B, Yang C, Zen K, Zhang CY. Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem 2010,56, 1871–1879

 

联系方式
 

Email: zchunni27@hotmail.com
电话:025-80863082